Педагогічні умови вокально-хорової підготовки студентів факультетів мистецтв педагогічних університетів

The article reveals the peculiarities of the implementation of pedagogical conditions of vocal and choral training of future teachers of music. Pedagogical conditions are defined as ways to ensure the effective implementation of artistic activity. The main pedagogical conditions for the formation of vocal and choral training of students of the faculties of arts of pedagogical universities we have identified: ensuring the interaction of cognitive, evaluative and creative activities of students of the faculties of arts; integrative combination of classroom and extracurricular types of educational, independent, concert-practical activity of students of faculties of arts in the process of their vocal-choral preparation for practical work with students; creation of a professional and creative educational environment for future music teachers in the process of vocal and choral preparation for productive activities. The above pedagogical conditions of vocal and choral training of future teachers of music contribute to the successful solution of urgent tasks, the positive course of educational activities in the process of pedagogical practice with students.Key words: students of faculties of arts of pedagogical universities, pedagogical conditions, vocal and choral training, efficiency of training.У статті розкритті особливості реалізації педагогічних умов вокально-хорової підготовки майбутніх учителів музичного мистецтва. Педагогічні умови визначенні як віднайдені шляхи забезпечення ефективного здійснення мистецької діяльності. Основними педагогічними умовами формування вокально-хорової підготовленості студентів факультетів мистецтв педагогічних університетів нами визначено: забезпечення взаємодії пізнавальної, оцінювальної та творчої діяльності студентів факультетів мистецтв; інтегративне поєднання аудиторної та позааудиторної різновидів навчальної, самостійної, концертно-практичної діяльності студентів факультетів мистецтв у процесі їх вокально-хорової підготовки до практичної роботи з учнями; створення професійно-творчого навчального середовища майбутніх учителів музичного мистецтва в процесі вокально-хорової підготовки до продуктивної діяльності. Вищезазначені педагогічні умови вокально-хорової підготовленості майбутніх учителів музичного мистецтва сприяють успішному вирішенню нагальних завдань, позитивному перебігу навчальної діяльності у процесі педагогічної практики з учнями. Ключові слова: студенти факультетів мистецтв педагогічних університетів, педагогічні умови, вокально-хорова підготовка, ефективність навчання

The properties of small magnetic flux ropes inside the solar wind come from coronal holes, active regions, and quiet Sun

The origination and generation mechanisms of small magnetic flux ropes (SFRs), which are important structures in solar wind, are not clearly known. In present study, 1993 SFRs immersed in coronal holes, active regions, and quiet Sun solar wind are analyzed and compared. We find that the properties of SFRs immersed in three types of solar wind are signicantly different. The SFRs are further classifed into hot-SFRs, cold-SFRs, and normal-SFRs, according to whether the O7+/O6+ is 30% elevated or dropped inside SFRs as compared with background solar wind. Our studies show that the parameters of normal-SFRs are similar to background in all three types of solar wind. The properties of hot-SFRs and cold-SFRs seem to be lying in two extremes. Statistically, the hot-SFRs (cold-SFRs) are associated with longer (shorter) duration, lower (higher) speeds and proton temperatures, higher (lower) charge states, helium abundance, and FIP bias as compared with normal-SFRs and background solar wind. The anti-correlations between speed and O7+/O6+ inside hot-SFRs (normal-SFRs) are different from (similar to) those in background solar wind. Most of hot-SFRs and cold-SFRs should come from the Sun. Hot-SFRs may come from streamers associated with plasma blobs and/or small-scale activities on the Sun. Cold-SFRs may be accompanied by small-scale eruptions with lower-temperature materials. Both hot-SFRs and cold-SFRs could also be formed by magnetic erosions of ICMEs that do not contain or contain cold-filament materials. The characteristics of normal-SFRs can be explained reasonably by the two originations, from the Sun and generated in the heliosphere both.Comment: 19 pages, 5 figure

Conditional Image-to-Video Generation with Latent Flow Diffusion Models

Conditional image-to-video (cI2V) generation aims to synthesize a new plausible video starting from an image (e.g., a person's face) and a condition (e.g., an action class label like smile). The key challenge of the cI2V task lies in the simultaneous generation of realistic spatial appearance and temporal dynamics corresponding to the given image and condition. In this paper, we propose an approach for cI2V using novel latent flow diffusion models (LFDM) that synthesize an optical flow sequence in the latent space based on the given condition to warp the given image. Compared to previous direct-synthesis-based works, our proposed LFDM can better synthesize spatial details and temporal motion by fully utilizing the spatial content of the given image and warping it in the latent space according to the generated temporally-coherent flow. The training of LFDM consists of two separate stages: (1) an unsupervised learning stage to train a latent flow auto-encoder for spatial content generation, including a flow predictor to estimate latent flow between pairs of video frames, and (2) a conditional learning stage to train a 3D-UNet-based diffusion model (DM) for temporal latent flow generation. Unlike previous DMs operating in pixel space or latent feature space that couples spatial and temporal information, the DM in our LFDM only needs to learn a low-dimensional latent flow space for motion generation, thus being more computationally efficient. We conduct comprehensive experiments on multiple datasets, where LFDM consistently outperforms prior arts. Furthermore, we show that LFDM can be easily adapted to new domains by simply finetuning the image decoder. Our code is available at https://github.com/nihaomiao/CVPR23_LFDM.Comment: CVPR 202

Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease

The porcine epidemic diarrhea virus (PEDV) is an Alphacoronavirus (α-CoV) that causes high mortality in infected piglets, resulting in serious economic losses in the farming industry. Hypericin is a dianthrone compound that has been shown as an antiviral activity on several viruses. Here, we first evaluated the antiviral effect of hypericin in PEDV and found the viral replication and egression were significantly reduced with hypericin post-treatment. As hypericin has been shown in SARS-CoV-2 that it is bound to viral 3CLpro, we thus established a molecular docking between hypericin and PEDV 3CLpro using different software and found hypericin bound to 3CLpro through two pockets. These binding pockets were further verified by another docking between hypericin and PEDV 3CLpro pocket mutants, and the fluorescence resonance energy transfer (FRET) assay confirmed that hypericin inhibits the PEDV 3CLpro activity. Moreover, the alignments of α-CoV 3CLpro sequences or crystal structure revealed that the pockets mediating hypericin and PEDV 3CLpro binding were highly conserved, especially in transmissible gastroenteritis virus (TGEV). We then validated the anti-TGEV effect of hypericin through viral replication and egression. Overall, our results push forward that hypericin was for the first time shown to have an inhibitory effect on PEDV and TGEV by targeting 3CLpro, and it deserves further attention as not only a pan-anti-α-CoV compound but potentially also as a compound of other coronaviral infections

Dietary Calcium but Not Elemental Calcium from Supplements Is Associated with Body Composition and Obesity in Chinese Women

We assessed whether dietary calcium intake or calcium supplements associated with body composition and obesity in a Chinese population.A cross-sectional survey was performed in a population of 8940, aged 20 to 74 y. 8127 participants responded (90.9%). Height, weight, fat mass (FM), waist circumference (WC) and hip circumference were measured. Obesity definition: body mass index (BMI) ≥28 kg/m(2) (overall obesity); WC ≥85 cm for men or ≥80 cm for women (abdominal obesity І) and waist hip ratio (WHR) ≥0.90 for men or ≥0.85 for women (abdominal obesity П). The data on dietary calcium and calcium supplements were collected using food-frequency questionnaire and self-report questionnaire. Multivariate linear and multivariable logistic regressions were used to examine the associations between dietary calcium intake or calcium supplements and body composition and obesity.The average dietary calcium intake of all subjects was 430 mg/d. After adjusting for potential confounding factors, among women only, negative associations were observed between habitual dietary calcium intake and four measures of body composition (β, -0.086, P<0.001 for BMI; β, -0.072, P<0.001 for WC; β, -0.044, P<0.05 for WHR; and β, -0.058, P<0.01 for FM, respectively) and both measures of abdominal obesity (Odds Ratio [OR] = 0.86, 95% Confidence Interval [CI], 0.80-0.93; P<0.001, for abdominal obesity I; OR = 0.92, 95% CI, 0.86-0.99; P = 0.026, for abdominal obesity II). These associations were not observed among men (P>0.05). Similarly, among both men and women, we did not observe significant associations between calcium supplements and any measures of body composition or abdominal obesity (P>0.05).Dietary calcium from food rather than elemental calcium from calcium supplements has beneficial effects on the maintenance of body composition and preventing abdominal obesity in Chinese women

Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human-machine interfaces

Existing electronic skin (e-skin) sensing platforms are equipped to monitor physical parameters using power from batteries or near-field communication. For e-skins to be applied in the next generation of robotics and medical devices, they must operate wirelessly and be self-powered. However, despite recent efforts to harvest energy from the human body, self-powered e-skin with the ability to perform biosensing with Bluetooth communication are limited because of the lack of a continuous energy source and limited power efficiency. Here, we report a flexible and fully perspiration-powered integrated electronic skin (PPES) for multiplexed metabolic sensing in situ. The battery-free e-skin contains multimodal sensors and highly efficient lactate biofuel cells that use a unique integration of zero- to three-dimensional nanomaterials to achieve high power intensity and long-term stability. The PPES delivered a record-breaking power density of 3.5 milliwatt·centimeter⁻² for biofuel cells in untreated human body fluids (human sweat) and displayed a very stable performance during a 60-hour continuous operation. It selectively monitored key metabolic analytes (e.g., urea, NH₄⁺, glucose, and pH) and the skin temperature during prolonged physical activities and wirelessly transmitted the data to the user interface using Bluetooth. The PPES was also able to monitor muscle contraction and work as a human-machine interface for human-prosthesis walking

CAMKs support development of acute myeloid leukemia.

BACKGROUND: We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also demonstrated that PirB is important for the development of acute myeloid leukemia (AML), but exactly how an inhibitory receptor such as PirB can support cancer development is intriguing. RESULTS: Here, we showed that the activation of Ca (2+)/calmodulin-dependent protein kinases (CAMKs) is coupled with PirB signaling in AML cells. High expression of CAMKs is associated with a poor overall survival probability in patients with AML. Knockdown of CAMKI or CAMKIV decreased human acute leukemia development in vitro and in vivo. Mouse AML cells that are defective in PirB signaling had decreased activation of CAMKs, and the forced expression of CAMK partially rescued the PirB-defective phenotype in the MLL-AF9 AML mouse model. The inhibition of CAMK kinase activity or deletion of CAMKIV significantly slowed AML development and decreased the AML stem cell activity. We also found that CAMKIV acts through the phosphorylation of one of its well-known target (CREB) in AML cells. CONCLUSION: CAMKs are essential for the growth of human and mouse AML. The inhibition of CAMK signaling may become an effective strategy for treating leukemia

Optimal mathematical programming and variable neighborhood search for k-modes categorical data clustering

The conventional k-modes algorithm and its variants have been extensively used for categorical data clustering. However, these algorithms have some drawbacks, e.g., they can be trapped into local optima and sensitive to initial clusters/modes. Our numerical experiments even showed that the k-modes algorithm could not identify the optimal clustering results for some special datasets regardless the selection of the initial centers. In this paper, we developed an integer linear programming (ILP) approach for the k-modes clustering, which is independent to the initial solution and can obtain directly the optimal results for small-sized datasets. We also developed a heuristic algorithm that implements iterative partial optimization in the ILP approach based on a framework of variable neighborhood search, known as IPO-ILP-VNS, to search for near-optimal results of medium and large sized datasets with controlled computing time. Experiments on 38 datasets, including 27 synthesized small datasets and 11 known benchmark datasets from the UCI site were carried out to test the proposed ILP approach and the IPO-ILP-VNS algorithm. The experimental results outperformed the conventional and other existing enhanced k-modes algorithms in literature, updated 9 of the UCI benchmark datasets with new and improved results

Mangiferin Decreases Plasma Free Fatty Acids through Promoting Its Catabolism in Liver by Activation of AMPK

Mangiferin has been shown to have the effect of improving dyslipidemia. Plasma free fatty acids (FFA) are closely associated with blood lipid metabolism as well as many diseases including metabolic syndrome. This study is to investigate whether mangiferin has effects on FFA metabolism in hyperlipidemic rats. Wistar rats were fed a high-fat diet and administered mangiferin simultaneously for 6 weeks. Mangiferin (50, 100, 150 mg/kg BW) decreased dose-dependently FFA and triglycerides (TG) levels in plasma, and their accumulations in liver, but increased the β-hydroxybutyrate levels in both plasma and liver of hyperlipidemic rats. HepG2 cells were treated with oleic acid (OA, 0.2 mmol/L) to simulate the condition of high level of plasma FFA in vitro, and were treated with different concentrations of mangiferin simultaneously for 24 h. We found that mangiferin significantly increased FFA uptake, significantly decreased intracellular FFA and TG accumulations in HepG2 cells. Mangiferin significantly increased AMP-activated protein kinase (AMPK) phosphorylation and its downstream proteins involved in fatty acid translocase (CD36) and carnitine palmitoyltransferase 1 (CPT1), but significantly decreased acyl-CoA: diacylgycerol acyltransferase 2 (DGAT2) expression and acetyl-CoA carboxylase (ACC) activity by increasing its phosphorylation level in both in vivo and in vitro studies. Furthermore, these effects were reversed by Compound C, an AMPK inhibitor in HepG2 cells. For upstream of AMPK, mangiferin increased AMP/ATP ratio, but had no effect on LKB1 phosphorylation. In conclusion, mangiferin decreased plasma FFA levels through promoting FFA uptake and oxidation, inhibiting FFA and TG accumulations by regulating the key enzymes expression in liver through AMPK pathway. Therefore, mangiferin is a possible beneficial natural compound for metabolic syndrome by improving FFA metabolism